Interleukin 12b (IL12B) (Middle Region) Peptide
IL12B
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN5511888
Quick Overview for Interleukin 12b (IL12B) (Middle Region) Peptide (ABIN5511888)
Target
IL12B
(Interleukin 12 beta (IL12B))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- YTSSFFIRDI IKPDPPKNLQ LKPLKNSRQV EVSWEYPDTW STPHSYFSLT
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-IL12B Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- IL12B (Interleukin 12 beta (IL12B))
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Background
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This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.
Alias Symbols: CLMF, NKSF, CLMF2, IMD28, IMD29, NKSF2, IL-12B
Protein Size: 328 -
Gene ID
- 3593
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NCBI Accession
- NM_002187, NP_002178
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UniProt
- P29460
Target
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